Discovery of TAK-272: a novel, potent, and orally active renin inhibitor
Y Imaeda, H Tokuhara, Y Fukase… - ACS Medicinal …, 2016 - ACS Publications
… than its enantiomer 4, measured either in rh-renin assay (IC 50 = … piperidine 3- and 5-positions
is important in determining renin … design of a new series of N-(piperidin-3-yl)pyrimidine-5-…
is important in determining renin … design of a new series of N-(piperidin-3-yl)pyrimidine-5-…
Decades-old renin inhibitors are still struggling to find a niche in antihypertensive therapy. A fleeting look at the old and the promising new molecules
… of renin inhibitors from several decades, the old discovery of peptides … designed (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides
as a potent …
as a potent …